Dr. Clark Store's Blog

    Killer Chemical Disguised As A Safe OTC Drug

    Posted by Stacy Facko on Thu, Sep 08, 2016 @ 03:06 PM

    Pain_Relief_Aisle.pngFrom time to time, we all experience pain. Whether it’s from the occasional pulled muscle, monthly menstrual cramps, or recovery from an injury, we just want to make it go away – and fast!

    Our culture has made it customary to seek relief by pill popping. And it’s easy to do with a plethora of over the counter pain medications available today designed to fit our preferences – liquid, capsule, tablet, chewable, flavored, non-drowsy, for daytime, for nighttime.

    The OTC drug industry shows no signs of slowing down, even as wise consumers are starting to re-think what goes into those OTC concoctions and the potential harm extended use can cause, like side effects, exposure to toxins and permanent organ damage.

    And one of the big offenders is acetaminophen, which can also be lurking on your drug facts panel under the name paracetamol.


    Why We Fell for Its Promises of Pain Relief

    Acetaminophen falls under the drug classifications of pain reliever (analgesic) and fever reducer (antipyretic). It relieves pain by elevating your pain threshold and reduces fever by chemically telling the brain’s heat-regulating center to lower body temperature when it’s elevated.

    Acetaminophen has been available as a non-prescription pain reliever in the US since the 1960s. You possibly know it by one its generic drug names:

    Actifed Dayquil Midol Robitussin Theraflu
    Alka-Seltzer Plus Dimetapp Muncinex Sinutab Tylenol
    Anacin Excedrin Nyquil Sudafed Vicks

    It’s easy to see why we’re drawn to this miracle drug. It’s readily available without a prescription. It’s affordable. It comes in formulas deemed safe for children. It can be combined with decongestants, antihistamines and sleep aids to combat colds and allergies. And it can mean relief from minor pain and fever, curtailing a trip to your doctor’s office.

    According to LiverTox, more than 25 billion doses of acetaminophen are sold each year in the US alone.

    And although its discovery has brought relief to millions over the years, it’s not without a dark side that pharmaceutical companies don’t like to highlight.


    How It’s Tightening the Noose Around Your Liver

    The manufacturers and even some physicians claim acetaminophen is harmless at low doses. However, it can be toxic to your liver at higher doses or when used for prolonged periods. Acute liver damage and even death from acute liver failure is a possibility.

    Hepatotoxicity, or chemical-driven liver damage, is a cause of both acute and chronic liver disease. As a main filter organ, the liver clears out toxins and wastes from the body. But if the liver becomes overwhelmed, damage can ensue.

    Acetaminophen itself is not the likely cause of said damage, rather it’s the metabolite n-acetyl-p-benzoquinone imine (NAPQI) produced by liver enzymes during the break down of acetaminophen. Under normal conditions NAPQI interacts with glutathione to be detoxified and secreted. But taking too much acetaminophen increases the level of NAPQI and can short circuit the detoxification process, leading to liver cell damage.

    Acetaminophen doses of four grams daily can lead to elevated serum aminotransferase, an increase of liver enzymes that indicate liver damage. Someone with severe or chronic pain might be taking larger or more frequent doses than suggested. Just 3-7 days of high or frequent dosing can start the damage, which generally has no symptoms to alert you that something could be worng.

    The FDA makes manufacturers of OTC acetaminophen products note the potential damage to the liver on drug packaging:

    Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take • more than 4,000 mg of acetaminophen in 24 hours • with other drugs containing acetaminophen • 3 or more alcoholic drinks every day while using this product.

    Acetaminophen is also present in several prescription drugs including:

    Hydrocet Norco Percocet Vivodin
    Hydrocodone Oxycodone Tapanol Zydone

    Even when sticking to the manufacturer’s suggested use, if combined with other acetaminophen-containing drugs, consumers may be unaware of how much acetaminophen they’re actually ingesting. Overdose from prescription combination products containing acetaminophen account for nearly half of all cases of acetaminophen-related liver failure in the US.


    Reversing the Damage

    Too much acetaminophen doesn’t have to mean a death sentence. The liver is a regenerating organ, meaning damaged sections can be regrown to return functionality. Minor aminotransferase elevation can be resolved by discontinuing acetaminophen, often without lasting effects.

    An overdose, however, can cause acute liver injury and liver failure that can result in death or the need for a liver transplant. According to LiverTox, acetaminophen is the major cause of acute liver failure in the US, Europe and Australia.

    Liver injury from acetaminophen can be prevented or reversed with a substantial increase of glutathione in the liver. This can be done with n-acetyl cysteine (NAC), a non-prescription amino acid derivative that is a precursor to glutathione production. In fact, it’s standard practice to administer NAC in cases of acetaminophen overdose. Details of administration and assistance can be obtained from Poison Control Centers.

    So if you’re taking OTC or prescription drugs with acetaminophen, it may be wise to take NAC to counteract the toxic effects to your liver.


    Other Unwanted Side Effect

    Liver damage aside, pain medications are notorious for causing constipation. If you’re taking pain meds, including acetaminophen, be sure to boost your fiber intake and drink plenty of water to keep things moving.

    Other unpleasant side effects may include nausea, itchiness or rash, and drowsiness or a sluggish mental state. 


    What’s the Alternative?

    Acute and chronic pain management doesn’t have to mean pumping your system with potentially toxic chemicals. There are a number of natural solutions that are toxin-free, addition and dependency-free, readily available (most without prescription), and affordable even if your insurance won’t cover them. Talk to a naturopathic doctor about customizing a pain management plan that incorporates these alternative practices to meet your needs.

    Alternative Therapies: Massage, acupuncture, cupping and chiropractic sessions can promote blood circulation and influence processes that regulate immune function to help the healing process and reduce pain and inflammation.

    Medical Marijuana: Cannabis can be taken in a variety of forms, including consumables, smoking, vaporizing or applying as a topical cream. There is strong opposition from Big Pharma to legalize marijuana in the US because that would eat away at their bottom line if cannabis took the place of many synthetic drugs that provide the same benefits for pain management, anxiety disorders, sleep disorders and seizures.

    Ice and Heat: Use ice for acute injuries, to minimize blood flow and reduce swelling and pain. Use heat to loosen muscles and stiff joints and to help regain mobility.

    Supplements: A number of herbs, essential oils and other nutraceuticals can help to relieve minor pain and inflammation. Curcumin, ginger, bromelain and the omega-3 fatty acid DHA can help to inhibit prostaglandins that trigger pain, fever and inflammation. Topical applications with essential oils or capsaicin can dull the pain of sore muscles and joints.

    Topics: liver health

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